BindingDB PrimarySearch

BDBM50302903 7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine::CHEMBL565843::US9066954, 172

SMILES: COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1

InChI Key: InChIKey=GTZBFNQZVAGCGW-UHFFFAOYSA-N

Data: 1 KI 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50302903
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50302903 (7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	2.70	-11.8	n/a	n/a	n/a	n/a	n/a	8.0	27
Amgen Inc. US Patent					Assay Description A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...				US Patent US9066954 (2015) BindingDB Entry DOI: 10.7270/Q2N878JD
Amgen Inc. US Patent					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50302903 (7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassay				Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50302903 (7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPH				Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50302903 (7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met by HTRF assay				Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50302903 (7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human CYP3A4				Bioorg Med Chem Lett 19: 6307-12 (2009) Article DOI: 10.1016/j.bmcl.2009.09.096 BindingDB Entry DOI: 10.7270/Q2DV1JZH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair