BDBM50303049 (S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopropoxy-1H-pyrazol-3-yl)pyrazine-2,6-diamine::CHEMBL576286

SMILES: CC(C)Oc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)[nH]n1

InChI Key: InChIKey=NGMZLWDETZHMAI-NSHDSACASA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50303049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50303049 ((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopr...) Show SMILES CC(C)Oc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)[nH]n1 |r| Show InChI InChI=1S/C17H20FN7O/c1-10(2)26-17-6-14(24-25-17)22-16-9-19-8-15(23-16)21-11(3)13-5-4-12(18)7-20-13/h4-11H,1-3H3,(H3,21,22,23,24,25)/t11-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	421	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of JAK2 using 5 mM ATP as a substrate				Bioorg Med Chem Lett 19: 6524-8 (2009) Article DOI: 10.1016/j.bmcl.2009.10.054 BindingDB Entry DOI: 10.7270/Q2CV4HT4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50303049 ((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopr...) Show SMILES CC(C)Oc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)[nH]n1 |r| Show InChI InChI=1S/C17H20FN7O/c1-10(2)26-17-6-14(24-25-17)22-16-9-19-8-15(23-16)21-11(3)13-5-4-12(18)7-20-13/h4-11H,1-3H3,(H3,21,22,23,24,25)/t11-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of JAK3 using 5 mM ATP as a substrate				Bioorg Med Chem Lett 19: 6524-8 (2009) Article DOI: 10.1016/j.bmcl.2009.10.054 BindingDB Entry DOI: 10.7270/Q2CV4HT4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50303049 ((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopr...) Show SMILES CC(C)Oc1cc(Nc2cncc(N[C@@H](C)c3ccc(F)cn3)n2)[nH]n1 |r| Show InChI InChI=1S/C17H20FN7O/c1-10(2)26-17-6-14(24-25-17)22-16-9-19-8-15(23-16)21-11(3)13-5-4-12(18)7-20-13/h4-11H,1-3H3,(H3,21,22,23,24,25)/t11-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Boston Curated by ChEMBL					Assay Description Inhibition of JAK2 using 2 mM ATP as a substrate				Bioorg Med Chem Lett 19: 6524-8 (2009) Article DOI: 10.1016/j.bmcl.2009.10.054 BindingDB Entry DOI: 10.7270/Q2CV4HT4
					More data for this Ligand-Target Pair