BDBM50303735 2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one::CHEMBL567259

SMILES: COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=KERCJRSYQSWRIP-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50303735 (2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-meth...) Show SMILES COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1 |t:17| Show InChI InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,15-8-10-17(11-9-15)33-23(24,25)26)16-6-3-5-14(13-16)18-7-4-12-28-19(18)32-2/h3-13H,1-2H3,(H2,27,29)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA				J Med Chem 53: 1146-58 (2010) Article DOI: 10.1021/jm901414e BindingDB Entry DOI: 10.7270/Q2SX6DBS
					More data for this Ligand-Target Pair
Cathepsin D (Homo sapiens (Human))	BDBM50303735 (2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-meth...) Show SMILES COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1 |t:17| Show InChI InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,15-8-10-17(11-9-15)33-23(24,25)26)16-6-3-5-14(13-16)18-7-4-12-28-19(18)32-2/h3-13H,1-2H3,(H2,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human cathepsin D by FRET based peptide cleavage assay				J Med Chem 53: 1146-58 (2010) Article DOI: 10.1021/jm901414e BindingDB Entry DOI: 10.7270/Q2SX6DBS
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM50303735 (2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-meth...) Show SMILES COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1 |t:17| Show InChI InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,15-8-10-17(11-9-15)33-23(24,25)26)16-6-3-5-14(13-16)18-7-4-12-28-19(18)32-2/h3-13H,1-2H3,(H2,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human BACE2 by FRET based peptide cleavage assay				J Med Chem 53: 1146-58 (2010) Article DOI: 10.1021/jm901414e BindingDB Entry DOI: 10.7270/Q2SX6DBS
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50303735 (2-amino-4-(3-(2-methoxypyridin-3-yl)phenyl)-1-meth...) Show SMILES COc1ncccc1-c1cccc(c1)C1(N=C(N)N(C)C1=O)c1ccc(OC(F)(F)F)cc1 |t:17| Show InChI InChI=1S/C23H19F3N4O3/c1-30-20(31)22(29-21(30)27,15-8-10-17(11-9-15)33-23(24,25)26)16-6-3-5-14(13-16)18-7-4-12-28-19(18)32-2/h3-13H,1-2H3,(H2,27,29)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human BACE1 by FRET based peptide cleavage assay				J Med Chem 53: 1146-58 (2010) Article DOI: 10.1021/jm901414e BindingDB Entry DOI: 10.7270/Q2SX6DBS
					More data for this Ligand-Target Pair