BindingDB PrimarySearch

BDBM50303774 CHEMBL566340::phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide

SMILES: [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7]

InChI Key: InChIKey=YGMAIAXBJLVVLI-KLJDGLGGSA-N

Data: 10 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50303774
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Subtilisin/kexin type 6 (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Prohormone convertase 1 (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human PC1/3 expressed in Drosophila schneider 2 cells by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins				Bioorg Med Chem Lett 21: 4695-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.091 BindingDB Entry DOI: 10.7270/Q27W6CJR
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human furin by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Subtilisin/kexin type 5 (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human PC5/6 expressed in Drosophila schneider 2 cells by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Prohormone convertase 2 (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	312	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human PC2 expressed in Drosophila schneider 2 cells by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of plasmin				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Subtilisin/kexin type 7 (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.15E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assay				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of thrombin				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50303774 (CHEMBL566340 \| phenylacetyl-Arg-Val-Arg-4-amidinob...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Marburg Curated by ChEMBL					Assay Description Inhibition of factor 10a				J Med Chem 53: 1067-75 (2010) Article DOI: 10.1021/jm9012455 BindingDB Entry DOI: 10.7270/Q2DN455Q
Philipps University Marburg Curated by ChEMBL					More data for this Ligand-Target Pair