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SMILES: COc1ccc(cc1OC)C1=NN(CC(=O)NCCCn2ccnc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key: InChIKey=RRNXURXVGGKEOL-RBUKOAKNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304408   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50304408
PNG
(CHEMBL605935 | N-[3-(1H-Imidazol-1-yl)propyl]-2-[c...)
Show SMILES COc1ccc(cc1OC)C1=NN(CC(=O)NCCCn2ccnc2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:31,t:11|
Show InChI InChI=1S/C24H29N5O4/c1-32-20-9-8-17(14-21(20)33-2)23-18-6-3-4-7-19(18)24(31)29(27-23)15-22(30)26-10-5-12-28-13-11-25-16-28/h3-4,8-9,11,13-14,16,18-19H,5-7,10,12,15H2,1-2H3,(H,26,30)/t18-,19+/m0/s1
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Similars
Article
PubMed
n/an/a 14.3n/an/an/an/an/an/a



Kyoto 601-8550

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis

Bioorg Med Chem 17: 6959-70 (2009)


Article DOI: 10.1016/j.bmc.2009.08.014
BindingDB Entry DOI: 10.7270/Q2WH2Q26
More data for this
Ligand-Target Pair