BDBM50304413 CHEMBL596447::cis-2-[4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-benzyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCC4(CC3)OCCO4)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key: InChIKey=OQGFHEKSYOZJBE-IZZNHLLZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304413   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50304413 (CHEMBL596447 | cis-2-[4-(1,4-Dioxa-8-azaspiro[4.5]...) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCC4(CC3)OCCO4)cc2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:39,t:11| Show InChI InChI=1S/C31H37N3O5/c1-36-27-12-11-24(19-28(27)37-2)29-25-5-3-4-6-26(25)30(35)34(32-29)21-23-9-7-22(8-10-23)20-33-15-13-31(14-16-33)38-17-18-39-31/h3-4,7-12,19,25-26H,5-6,13-18,20-21H2,1-2H3/t25-,26+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 601-8550 Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis				Bioorg Med Chem 17: 6959-70 (2009) Article DOI: 10.1016/j.bmc.2009.08.014 BindingDB Entry DOI: 10.7270/Q2WH2Q26
					More data for this Ligand-Target Pair