BDBM50304414 CHEMBL603626::cis-4-(3,4-Dimethoxyphenyl)-2-[4-(piperidin-1-ylmethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCCCC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key: InChIKey=SEHHXWJFLFPSLC-LOSJGSFVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304414   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50304414 (CHEMBL603626 | cis-4-(3,4-Dimethoxyphenyl)-2-[4-(p...) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCCCC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:34,t:11| Show InChI InChI=1S/C29H35N3O3/c1-34-26-15-14-23(18-27(26)35-2)28-24-8-4-5-9-25(24)29(33)32(30-28)20-22-12-10-21(11-13-22)19-31-16-6-3-7-17-31/h4-5,10-15,18,24-25H,3,6-9,16-17,19-20H2,1-2H3/t24-,25+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 601-8550 Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis				Bioorg Med Chem 17: 6959-70 (2009) Article DOI: 10.1016/j.bmc.2009.08.014 BindingDB Entry DOI: 10.7270/Q2WH2Q26
					More data for this Ligand-Target Pair