BDBM50304415 CHEMBL595038::cis-4-(3,4-Dimethoxyphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]benzyl}-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCN(C)CC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key: InChIKey=RFFLAHIRPVBZBQ-LOSJGSFVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50304415 (CHEMBL595038 | cis-4-(3,4-Dimethoxyphenyl)-2-{4-[(...) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCN(C)CC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:35,t:11| Show InChI InChI=1S/C29H36N4O3/c1-31-14-16-32(17-15-31)19-21-8-10-22(11-9-21)20-33-29(34)25-7-5-4-6-24(25)28(30-33)23-12-13-26(35-2)27(18-23)36-3/h4-5,8-13,18,24-25H,6-7,14-17,19-20H2,1-3H3/t24-,25+/m0/s1	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 601-8550 Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis				Bioorg Med Chem 17: 6959-70 (2009) Article DOI: 10.1016/j.bmc.2009.08.014 BindingDB Entry DOI: 10.7270/Q2WH2Q26
					More data for this Ligand-Target Pair