BDBM50304423 CHEMBL595272::cis-4-(3,4-Dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

SMILES: COc1ccc(cc1OC)C1=NN(Cc2ccccc2CN2CCOCC2)C(=O)[C@@H]2CCCC[C@H]12

InChI Key: InChIKey=AEUMWBGWKJJBGE-BJKOFHAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50304423 (CHEMBL595272 | cis-4-(3,4-Dimethoxyphenyl)-2-[4-(m...) Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccccc2CN2CCOCC2)C(=O)[C@@H]2CCCC[C@H]12 |r,t:11| Show InChI InChI=1S/C28H35N3O4/c1-33-25-12-11-20(17-26(25)34-2)27-23-9-5-6-10-24(23)28(32)31(29-27)19-22-8-4-3-7-21(22)18-30-13-15-35-16-14-30/h3-4,7-8,11-12,17,23-24H,5-6,9-10,13-16,18-19H2,1-2H3/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto 601-8550 Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysis				Bioorg Med Chem 17: 6959-70 (2009) Article DOI: 10.1016/j.bmc.2009.08.014 BindingDB Entry DOI: 10.7270/Q2WH2Q26
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