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BDBM50305433 2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)-1H-pyrazol-4-yl)acetonitrile::CHEMBL590382

SMILES: Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)N1CCN(CC1)c1ncccn1

InChI Key: InChIKey=DFQBPUMPONTPNH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50305433   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50305433
PNG
(2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-3-(4-(pyr...)
Show SMILES Clc1ccc(cc1)-c1c(CC#N)c(nn1-c1ccccc1Cl)C(=O)N1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C26H21Cl2N7O/c27-19-8-6-18(7-9-19)24-20(10-11-29)23(32-35(24)22-5-2-1-4-21(22)28)25(36)33-14-16-34(17-15-33)26-30-12-3-13-31-26/h1-9,12-13H,10,14-17H2
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PC cid
PC sid
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Patents

Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS binding


Bioorg Med Chem Lett 20: 26-30 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.047
BindingDB Entry DOI: 10.7270/Q28G8KS9
More data for this
Ligand-Target Pair