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BDBM50306119 6-(6-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide::CHEMBL596363

SMILES: OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(O)c1cc(F)ccc1O2)c1ccccc1

InChI Key: InChIKey=YAVXHXQBLJBHMD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50306119   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA desaturase 1


(Mus musculus)		BDBM50306119
PNG
(6-(6-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine...)
Show SMILES OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CC(O)c1cc(F)ccc1O2)c1ccccc1
Show InChI InChI=1S/C26H27FN4O4/c27-18-6-8-23-19(14-18)21(32)15-26(35-23)10-12-31(13-11-26)24-9-7-20(29-30-24)25(34)28-16-22(33)17-4-2-1-3-5-17/h1-9,14,21-22,32-33H,10-13,15-16H2,(H,28,34)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of SCD1 in mouse microsomal liver S9 microsomal fraction assessed as conversion of [14C]stearate to [14C]oleate after 60 mins

Bioorg Med Chem Lett 20: 746-54 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.043
BindingDB Entry DOI: 10.7270/Q28C9WBJ
More data for this
Ligand-Target Pair