BindingDB PrimarySearch

BDBM50306161 3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyrazolo[4,3-b]pyrazin-5-yl)-6-(2-methylfuran-3-yl)pyridin-2-amine::CHEMBL594755

SMILES: Cc1n[nH]c2ncc(nc12)-c1cc(OC[C@@H](N)Cc2ccccc2)c(N)nc1-c1ccoc1C

InChI Key: InChIKey=SSMMEOSYEUOMIT-KRWDZBQOSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50306161
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50306161 (3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human AKT1				Bioorg Med Chem Lett 20: 684-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.061 BindingDB Entry DOI: 10.7270/Q20V8CXX
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50306161 (3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human AKT2				Bioorg Med Chem Lett 20: 684-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.061 BindingDB Entry DOI: 10.7270/Q20V8CXX
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50306161 (3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 20: 684-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.061 BindingDB Entry DOI: 10.7270/Q20V8CXX
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50306161 (3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GSK2beta phosphorylation in human BT474 cells				Bioorg Med Chem Lett 20: 684-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.061 BindingDB Entry DOI: 10.7270/Q20V8CXX
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50306161 (3-((S)-2-amino-3-phenylpropoxy)-5-(3-methyl-1H-pyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human AKT3				Bioorg Med Chem Lett 20: 684-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.061 BindingDB Entry DOI: 10.7270/Q20V8CXX
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair