BDBM50306296 4-(1-(cyclopropylmethyl)-4-(3-hydroxyphenyl)piperidin-4-yl)-N,N-diethylbenzamide::CHEMBL595245
SMILES: CCN(CC)C(=O)c1ccc(cc1)C1(CCN(CC2CC2)CC1)c1cccc(O)c1
InChI Key: InChIKey=SFZRRWGLLPCDSK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50306296 (4-(1-(cyclopropylmethyl)-4-(3-hydroxyphenyl)piperi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [125I]diprenorphine from human delta opioid receptor expressed in CHO cells by liquid scintillation counting | Bioorg Med Chem Lett 20: 503-7 (2010) Article DOI: 10.1016/j.bmcl.2009.11.113 BindingDB Entry DOI: 10.7270/Q2C53KX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50306296 (4-(1-(cyclopropylmethyl)-4-(3-hydroxyphenyl)piperi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [125I]diprenorphine from human kappa opioid receptor expressed in CHO cells by liquid scintillation counting | Bioorg Med Chem Lett 20: 503-7 (2010) Article DOI: 10.1016/j.bmcl.2009.11.113 BindingDB Entry DOI: 10.7270/Q2C53KX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50306296 (4-(1-(cyclopropylmethyl)-4-(3-hydroxyphenyl)piperi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >890 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [125I]diprenorphine from human mu opioid receptor expressed in CHO cells by liquid scintillation counting | Bioorg Med Chem Lett 20: 503-7 (2010) Article DOI: 10.1016/j.bmcl.2009.11.113 BindingDB Entry DOI: 10.7270/Q2C53KX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50306296 (4-(1-(cyclopropylmethyl)-4-(3-hydroxyphenyl)piperi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at delta opioid receptor by GTPgammaS bunding assay | Bioorg Med Chem Lett 20: 503-7 (2010) Article DOI: 10.1016/j.bmcl.2009.11.113 BindingDB Entry DOI: 10.7270/Q2C53KX1 | |||||||||||
More data for this Ligand-Target Pair |