BDBM50306422 2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL597063

SMILES: Cc1cccc2c1C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3

InChI Key: InChIKey=RQGFSTVIFKBKGN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50306422 (2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dih...) Show SMILES Cc1cccc2c1C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:27:31:24.23.22,28:23:26.27.29:31,THB:22:23:26:29.30.31,22:30:26:24.28.23,21:22:26.27.29:31,(41.31,-1.21,;40.08,-2.14,;40.27,-3.66,;39.05,-4.59,;37.64,-3.99,;37.45,-2.47,;38.68,-1.55,;38.18,-.09,;38.95,1.24,;40.49,1.24,;41.27,-.09,;41.27,2.58,;36.64,-.12,;36.19,-1.6,;36.13,-3.14,;34.78,-3.87,;33.47,-3.05,;33.5,-1.51,;34.87,-.78,;32.12,-3.79,;32.08,-5.33,;30.8,-2.98,;29.44,-3.72,;29.43,-5.25,;28.04,-5.6,;26.71,-5.1,;25.51,-6.38,;27.01,-5.96,;28.42,-6.53,;27.01,-4.37,;28.05,-3.14,;26.7,-3.62,)| Show InChI InChI=1S/C27H36N2O3/c1-16-3-2-4-22-24(16)21(14-23(30)31)15-27(22)5-7-29(8-6-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-4,17-21,25H,5-15H2,1H3,(H,28,32)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPA				Bioorg Med Chem Lett 20: 881-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.082 BindingDB Entry DOI: 10.7270/Q2KK9BWZ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM50306422 (2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dih...) Show SMILES Cc1cccc2c1C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:27:31:24.23.22,28:23:26.27.29:31,THB:22:23:26:29.30.31,22:30:26:24.28.23,21:22:26.27.29:31,(41.31,-1.21,;40.08,-2.14,;40.27,-3.66,;39.05,-4.59,;37.64,-3.99,;37.45,-2.47,;38.68,-1.55,;38.18,-.09,;38.95,1.24,;40.49,1.24,;41.27,-.09,;41.27,2.58,;36.64,-.12,;36.19,-1.6,;36.13,-3.14,;34.78,-3.87,;33.47,-3.05,;33.5,-1.51,;34.87,-.78,;32.12,-3.79,;32.08,-5.33,;30.8,-2.98,;29.44,-3.72,;29.43,-5.25,;28.04,-5.6,;26.71,-5.1,;25.51,-6.38,;27.01,-5.96,;28.42,-6.53,;27.01,-4.37,;28.05,-3.14,;26.7,-3.62,)| Show InChI InChI=1S/C27H36N2O3/c1-16-3-2-4-22-24(16)21(14-23(30)31)15-27(22)5-7-29(8-6-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-4,17-21,25H,5-15H2,1H3,(H,28,32)(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD2				Bioorg Med Chem Lett 20: 881-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.082 BindingDB Entry DOI: 10.7270/Q2KK9BWZ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50306422 (2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dih...) Show SMILES Cc1cccc2c1C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:27:31:24.23.22,28:23:26.27.29:31,THB:22:23:26:29.30.31,22:30:26:24.28.23,21:22:26.27.29:31,(41.31,-1.21,;40.08,-2.14,;40.27,-3.66,;39.05,-4.59,;37.64,-3.99,;37.45,-2.47,;38.68,-1.55,;38.18,-.09,;38.95,1.24,;40.49,1.24,;41.27,-.09,;41.27,2.58,;36.64,-.12,;36.19,-1.6,;36.13,-3.14,;34.78,-3.87,;33.47,-3.05,;33.5,-1.51,;34.87,-.78,;32.12,-3.79,;32.08,-5.33,;30.8,-2.98,;29.44,-3.72,;29.43,-5.25,;28.04,-5.6,;26.71,-5.1,;25.51,-6.38,;27.01,-5.96,;28.42,-6.53,;27.01,-4.37,;28.05,-3.14,;26.7,-3.62,)| Show InChI InChI=1S/C27H36N2O3/c1-16-3-2-4-22-24(16)21(14-23(30)31)15-27(22)5-7-29(8-6-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-4,17-21,25H,5-15H2,1H3,(H,28,32)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19.7	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPA				Bioorg Med Chem Lett 20: 881-6 (2010) Article DOI: 10.1016/j.bmcl.2009.12.082 BindingDB Entry DOI: 10.7270/Q2KK9BWZ
					More data for this Ligand-Target Pair