null

SMILES: CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn([C@@H]3CC[C@@H](CC3)OC)c2n1

InChI Key: InChIKey=ZDYYEIJLRMPBFE-WHSGIHJSSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306631   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50306631 (CHEMBL601445 | cis-1-(4-(4-(8-oxa-3-azabicyclo[3.2...) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn([C@@H]3CC[C@@H](CC3)OC)c2n1 |r,wU:26.28,29.35,(3.04,-14.26,;4.37,-15.02,;5.7,-14.25,;5.7,-12.71,;7.04,-15.01,;8.37,-14.24,;8.36,-12.7,;9.69,-11.93,;11.03,-12.7,;11.03,-14.23,;9.71,-15.01,;12.35,-11.93,;12.35,-10.38,;13.69,-9.61,;13.69,-8.05,;12.35,-7.28,;12.35,-5.73,;12.94,-4.34,;14.45,-4.34,;15.04,-5.73,;15.04,-7.28,;13.69,-4.96,;15.04,-10.38,;16.5,-9.89,;17.42,-11.14,;16.51,-12.39,;16.99,-13.85,;16.19,-15.17,;16.93,-16.51,;18.47,-16.55,;19.27,-15.23,;18.53,-13.88,;19.21,-17.9,;18.41,-19.22,;15.04,-11.92,;13.69,-12.7,)| Show InChI InChI=1S/C26H33N7O3/c1-27-26(34)29-17-5-3-16(4-6-17)23-30-24(32-14-20-11-12-21(15-32)36-20)22-13-28-33(25(22)31-23)18-7-9-19(35-2)10-8-18/h3-6,13,18-21H,7-12,14-15H2,1-2H3,(H2,27,29,34)/t18-,19+,20?,21?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	705	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 20: 1440-4 (2010) Article DOI: 10.1016/j.bmcl.2009.12.086 BindingDB Entry DOI: 10.7270/Q2S46S2T
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50306631 (CHEMBL601445 | cis-1-(4-(4-(8-oxa-3-azabicyclo[3.2...) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CC3CCC(C2)O3)c2cnn([C@@H]3CC[C@@H](CC3)OC)c2n1 |r,wU:26.28,29.35,(3.04,-14.26,;4.37,-15.02,;5.7,-14.25,;5.7,-12.71,;7.04,-15.01,;8.37,-14.24,;8.36,-12.7,;9.69,-11.93,;11.03,-12.7,;11.03,-14.23,;9.71,-15.01,;12.35,-11.93,;12.35,-10.38,;13.69,-9.61,;13.69,-8.05,;12.35,-7.28,;12.35,-5.73,;12.94,-4.34,;14.45,-4.34,;15.04,-5.73,;15.04,-7.28,;13.69,-4.96,;15.04,-10.38,;16.5,-9.89,;17.42,-11.14,;16.51,-12.39,;16.99,-13.85,;16.19,-15.17,;16.93,-16.51,;18.47,-16.55,;19.27,-15.23,;18.53,-13.88,;19.21,-17.9,;18.41,-19.22,;15.04,-11.92,;13.69,-12.7,)| Show InChI InChI=1S/C26H33N7O3/c1-27-26(34)29-17-5-3-16(4-6-17)23-30-24(32-14-20-11-12-21(15-32)36-20)22-13-28-33(25(22)31-23)18-7-9-19(35-2)10-8-18/h3-6,13,18-21H,7-12,14-15H2,1-2H3,(H2,27,29,34)/t18-,19+,20?,21?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of mTOR				Bioorg Med Chem Lett 20: 1440-4 (2010) Article DOI: 10.1016/j.bmcl.2009.12.086 BindingDB Entry DOI: 10.7270/Q2S46S2T
					More data for this Ligand-Target Pair