BDBM50307481 (S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-phenylpropanamide::CHEMBL578478
SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)[C@@]1(C)CO1
InChI Key: InChIKey=XGLBOPYPKBXJKE-KGSCVCOFSA-N
Data: 15 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteasome component C5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of 26S proteasome beta 1 using nLPnLD as substrate | J Med Chem 53: 2319-23 (2010) Article DOI: 10.1021/jm9015685 BindingDB Entry DOI: 10.7270/Q2WS8TCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based competitive a... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome chymotrypsin-like (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of 26S proteasome beta 5 using LLVY as substrate | J Med Chem 53: 2319-23 (2010) Article DOI: 10.1021/jm9015685 BindingDB Entry DOI: 10.7270/Q2WS8TCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe based co... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe b... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe based co... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based compet... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based compet... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based competitive a... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
20S proteasome (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based compet... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe b... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of catalytic activity of constitutive proteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based compet... | J Med Chem 59: 7177-87 (2016) Article DOI: 10.1021/acs.jmedchem.6b00705 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome Macropain subunit (Homo sapiens (Human)) | BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of 26S proteasome beta 2 using RLR as substrate | J Med Chem 53: 2319-23 (2010) Article DOI: 10.1021/jm9015685 BindingDB Entry DOI: 10.7270/Q2WS8TCH | |||||||||||
More data for this Ligand-Target Pair |