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BDBM50308067 4-(4-tert-Butyl-phenyl)-1-isopropyl-6-methoxy-1H-quinazolin-2-one::CHEMBL599868

SMILES: COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)(C)C)c2c1

InChI Key: InChIKey=JPGLJHNGXAZHEX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308067   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50308067
PNG
(4-(4-tert-Butyl-phenyl)-1-isopropyl-6-methoxy-1H-q...)
Show SMILES COc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)(C)C)c2c1
Show InChI InChI=1S/C22H26N2O2/c1-14(2)24-19-12-11-17(26-6)13-18(19)20(23-21(24)25)15-7-9-16(10-8-15)22(3,4)5/h7-14H,1-6H3
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Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...

J Med Chem 53: 2250-63 (2010)


Article DOI: 10.1021/jm901811v
BindingDB Entry DOI: 10.7270/Q2Q240BT
More data for this
Ligand-Target Pair