BDBM50308072 6-Ethoxy-1-isopropyl-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one::CHEMBL608721

SMILES: CCOc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1

InChI Key: InChIKey=NRPKPAYBJWZZMX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50308072 (6-Ethoxy-1-isopropyl-4-(4-isopropyl-phenyl)-1H-qui...) Show SMILES CCOc1ccc2n(C(C)C)c(=O)nc(-c3ccc(cc3)C(C)C)c2c1 Show InChI InChI=1S/C22H26N2O2/c1-6-26-18-11-12-20-19(13-18)21(23-22(25)24(20)15(4)5)17-9-7-16(8-10-17)14(2)3/h7-15H,6H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...				J Med Chem 53: 2250-63 (2010) Article DOI: 10.1021/jm901811v BindingDB Entry DOI: 10.7270/Q2Q240BT
					More data for this Ligand-Target Pair