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SMILES: CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(NCc3ccccc3)cc12

InChI Key: InChIKey=GPVDDWUSJONEJY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308102   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50308102
PNG
(6-(Benzylylamino)-1-isopropyl-4-(4-isopropyl-pheny...)
Show SMILES CC(C)c1ccc(cc1)-c1nc(=O)n(C(C)C)c2ccc(NCc3ccccc3)cc12
Show InChI InChI=1S/C27H29N3O/c1-18(2)21-10-12-22(13-11-21)26-24-16-23(28-17-20-8-6-5-7-9-20)14-15-25(24)30(19(3)4)27(31)29-26/h5-16,18-19,28H,17H2,1-4H3
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...

J Med Chem 53: 2250-63 (2010)


Article DOI: 10.1021/jm901811v
BindingDB Entry DOI: 10.7270/Q2Q240BT
More data for this
Ligand-Target Pair