null

SMILES: Clc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1

InChI Key: InChIKey=UOPUPFLUHAWAOV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50308185 (2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d]...) Show SMILES Clc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 Show InChI InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-15(13)22-18-20-10-11-9-16(24)21-14-7-3-1-5-12(14)17(11)23-18/h1-8,10H,9H2,(H,21,24)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308185 (2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d]...) Show SMILES Clc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 Show InChI InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-15(13)22-18-20-10-11-9-16(24)21-14-7-3-1-5-12(14)17(11)23-18/h1-8,10H,9H2,(H,21,24)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50308185 (2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d]...) Show SMILES Clc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 Show InChI InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-15(13)22-18-20-10-11-9-16(24)21-14-7-3-1-5-12(14)17(11)23-18/h1-8,10H,9H2,(H,21,24)(H,20,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair