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SMILES: Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1Cl

InChI Key: InChIKey=PHOCQCHTHJNVPB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308206   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50308206 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrid...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1Cl Show InChI InChI=1S/C17H12ClN5O2/c18-11-7-10(3-4-13(11)24)21-17-20-8-9-6-14(25)22-12-2-1-5-19-16(12)15(9)23-17/h1-5,7-8,24H,6H2,(H,22,25)(H,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50308206 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrid...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1Cl Show InChI InChI=1S/C17H12ClN5O2/c18-11-7-10(3-4-13(11)24)21-17-20-8-9-6-14(25)22-12-2-1-5-19-16(12)15(9)23-17/h1-5,7-8,24H,6H2,(H,22,25)(H,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50308206 (2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrid...) Show SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1Cl Show InChI InChI=1S/C17H12ClN5O2/c18-11-7-10(3-4-13(11)24)21-17-20-8-9-6-14(25)22-12-2-1-5-19-16(12)15(9)23-17/h1-5,7-8,24H,6H2,(H,22,25)(H,20,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Braunschweig Curated by ChEMBL					Assay Description Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATP				J Med Chem 53: 2433-42 (2010) Article DOI: 10.1021/jm901388c BindingDB Entry DOI: 10.7270/Q24J0G22
					More data for this Ligand-Target Pair