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SMILES: COc1cc(on1)C(=O)Nc1nonc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1

InChI Key: InChIKey=WEVILATZZMPFBJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50309025   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
B1 bradykinin receptor


(Homo sapiens (Human))		BDBM50309025
PNG
(CHEMBL603668 | N-(4-((5'-chloro-3,3'-difluoro-2'-(...)
Show SMILES COc1cc(on1)C(=O)Nc1nonc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C23H16ClF2N7O5/c1-10-28-20(31-36-10)19-14(6-13(24)7-16(19)26)11-3-4-12(15(25)5-11)9-27-21-22(33-38-32-21)29-23(34)17-8-18(35-2)30-37-17/h3-8H,9H2,1-2H3,(H,27,32)(H,29,33,34)
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Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Jerini AG

Curated by ChEMBL


Assay Description
Antagonist activity at bradykinin B1 receptor in human IMR90 cells pretreated with IL1beta assessed as inhibition of DAKD-induced calcium mobilizatio...

Bioorg Med Chem Lett 20: 1229-32 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.120
BindingDB Entry DOI: 10.7270/Q2416X5W
More data for this
Ligand-Target Pair