BDBM50310488 (R)-3-((N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-(trifluoromethoxy)phenyl)acetamido)methyl)pyridine 1-oxide::CHEMBL1077832
SMILES: CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1ccc[n+]([O-])c1)C(=O)Cc1ccc(OC(F)(F)F)cc1
InChI Key: InChIKey=DMBGCHREERYYSP-OAQYLSRUSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
chemokine (C-X-C motif) receptor 3 (Homo sapiens (Human)) | BDBM50310488 ((R)-3-((N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [125I]-1P10 from human CXCR3 expressed in PBMC after 2 hrs in RPMI buffer by scintillation counting | Bioorg Med Chem Lett 19: 5114-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.032 BindingDB Entry DOI: 10.7270/Q2FX79KZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
chemokine (C-X-C motif) receptor 3 (Homo sapiens (Human)) | BDBM50310488 ((R)-3-((N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [125I]-IP-10 from CXCR3 | Bioorg Med Chem Lett 22: 357-62 (2011) Article DOI: 10.1016/j.bmcl.2011.10.120 BindingDB Entry DOI: 10.7270/Q2S75GS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
chemokine (C-X-C motif) receptor 3 (Homo sapiens (Human)) | BDBM50310488 ((R)-3-((N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [125I]-IP-10 from CXCR3 in presence of 100% human serum | Bioorg Med Chem Lett 22: 357-62 (2011) Article DOI: 10.1016/j.bmcl.2011.10.120 BindingDB Entry DOI: 10.7270/Q2S75GS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
chemokine (C-X-C motif) receptor 3 (Homo sapiens (Human)) | BDBM50310488 ((R)-3-((N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Antagonist activity against human CXCR3 expressed in human PBMC assessed as inhibition of cell migration in response to ITAC in plasma | Bioorg Med Chem Lett 19: 5114-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.032 BindingDB Entry DOI: 10.7270/Q2FX79KZ | |||||||||||
More data for this Ligand-Target Pair |