BDBM50311082 (1S,2R)-1-(5-(5-chloropyridin-2-yl)thiophene-2-sulfonamido)-2-phenylcyclopropanecarboxylic acid::CHEMBL1077892::US10322143, Shiozaki Ciompound 8

SMILES: OC(=O)[C@@]1(C[C@@H]1c1ccccc1)NS(=O)(=O)c1ccc(s1)-c1ccc(Cl)cn1

InChI Key: InChIKey=NNOZBVKNPNHPKF-KUHUBIRLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50311082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50311082 ((1S,2R)-1-(5-(5-chloropyridin-2-yl)thiophene-2-sul...) Show SMILES OC(=O)[C@@]1(C[C@@H]1c1ccccc1)NS(=O)(=O)c1ccc(s1)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C19H15ClN2O4S2/c20-13-6-7-15(21-11-13)16-8-9-17(27-16)28(25,26)22-19(18(23)24)10-14(19)12-4-2-1-3-5-12/h1-9,11,14,22H,10H2,(H,23,24)/t14-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...				Bioorg Med Chem Lett 19: 4280-3 (2009) BindingDB Entry DOI: 10.7270/Q2BC41VN
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50311082 ((1S,2R)-1-(5-(5-chloropyridin-2-yl)thiophene-2-sul...) Show SMILES OC(=O)[C@@]1(C[C@@H]1c1ccccc1)NS(=O)(=O)c1ccc(s1)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C19H15ClN2O4S2/c20-13-6-7-15(21-11-13)16-8-9-17(27-16)28(25,26)22-19(18(23)24)10-14(19)12-4-2-1-3-5-12/h1-9,11,14,22H,10H2,(H,23,24)/t14-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Central Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of ADAMTS5				Bioorg Med Chem Lett 19: 6213-7 (2009) Article DOI: 10.1016/j.bmcl.2009.08.093 BindingDB Entry DOI: 10.7270/Q2ZS2WMT
					More data for this Ligand-Target Pair