BDBM50312070 CHEMBL1080438::N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide

SMILES: Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc2c(cnn12)-c1cn[nH]c1

InChI Key: InChIKey=AHQVZQVSHSOLDM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50312070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50312070 (CHEMBL1080438 | N-(3-(3-(1H-pyrazol-4-yl)pyrazolo[...) Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnc2c(cnn12)-c1cn[nH]c1 Show InChI InChI=1S/C23H14F4N6O/c24-19-5-4-16(32-22(34)13-2-1-3-15(8-13)23(25,26)27)9-17(19)20-6-7-28-21-18(12-31-33(20)21)14-10-29-30-11-14/h1-12H,(H,29,30)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant B-Raf expressed in Sf9 cells				Bioorg Med Chem Lett 19: 6519-23 (2009) Article DOI: 10.1016/j.bmcl.2009.10.049 BindingDB Entry DOI: 10.7270/Q2SX6DC7
					More data for this Ligand-Target Pair