BDBM50312716 (S)-4'-cyclohexyl-2'-cyclopentyl-3'-((S)-fluoro(4-(trifluoromethyl)phenyl)methyl)-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinolin]-5'-ol::CHEMBL1081802
SMILES: O[C@H]1CC2(CCC2)Cc2nc(C3CCCC3)c([C@@H](F)c3ccc(cc3)C(F)(F)F)c(C3CCCCC3)c12
InChI Key: InChIKey=KVTOMNNOROBXFX-CUBQBAPOSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50312716 ((S)-4'-cyclohexyl-2'-cyclopentyl-3'-((S)-fluoro(4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of CETP assessed as cholesterol ester transfer after 4 hrs by microemulsion based fluorescence assay | Bioorg Med Chem Lett 20: 1740-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.071 BindingDB Entry DOI: 10.7270/Q28S4Q1P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50312716 ((S)-4'-cyclohexyl-2'-cyclopentyl-3'-((S)-fluoro(4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human plasma CETP assessed as [3H]cholesterol ester transfer after 18 hrs by scintillation proximity assay | Bioorg Med Chem Lett 20: 1740-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.071 BindingDB Entry DOI: 10.7270/Q28S4Q1P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50312716 ((S)-4'-cyclohexyl-2'-cyclopentyl-3'-((S)-fluoro(4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human plasma CETP assessed as cholesterol ester transfer after 24 hrs by fluorescence assay | Bioorg Med Chem Lett 20: 1740-3 (2010) Article DOI: 10.1016/j.bmcl.2010.01.071 BindingDB Entry DOI: 10.7270/Q28S4Q1P | |||||||||||
More data for this Ligand-Target Pair |