null

SMILES: Cc1cc2cc(ccc2cn1)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1

InChI Key: InChIKey=JITNHYKCFBSHCI-IBGZPJMESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312753   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50312753 ((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...) Show SMILES Cc1cc2cc(ccc2cn1)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C22H20F3N5S/c1-13-8-17-10-15(4-5-16(17)11-27-13)20-29-30-21(31-20)28-12-19(26)9-14-2-6-18(7-3-14)22(23,24)25/h2-8,10-11,19H,9,12,26H2,1H3,(H,28,30)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	607	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 20: 1652-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.046 BindingDB Entry DOI: 10.7270/Q21836MC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50312753 ((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...) Show SMILES Cc1cc2cc(ccc2cn1)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1 |r| Show InChI InChI=1S/C22H20F3N5S/c1-13-8-17-10-15(4-5-16(17)11-27-13)20-29-30-21(31-20)28-12-19(26)9-14-2-6-18(7-3-14)22(23,24)25/h2-8,10-11,19H,9,12,26H2,1H3,(H,28,30)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1 after 10 mins by [gamma33]ATP assay				Bioorg Med Chem Lett 20: 1652-6 (2010) Article DOI: 10.1016/j.bmcl.2010.01.046 BindingDB Entry DOI: 10.7270/Q21836MC
					More data for this Ligand-Target Pair