null

SMILES: N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=HVKMMDVZQKUXML-IBGZPJMESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50312924 ((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...) Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 20: 1559-64 (2010) Article DOI: 10.1016/j.bmcl.2010.01.067 BindingDB Entry DOI: 10.7270/Q20C4VWX
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50312924 ((S)-N1-(3-(isoquinolin-6-yl)isoxazol-5-yl)-3-(4-(t...) Show SMILES N[C@H](CNc1cc(no1)-c1ccc2cnccc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)18-5-1-14(2-6-18)9-19(26)13-28-21-11-20(29-30-21)16-3-4-17-12-27-8-7-15(17)10-16/h1-8,10-12,19,28H,9,13,26H2/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA				Bioorg Med Chem Lett 20: 1559-64 (2010) Article DOI: 10.1016/j.bmcl.2010.01.067 BindingDB Entry DOI: 10.7270/Q20C4VWX
					More data for this Ligand-Target Pair