BDBM50313131 1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-indole::CHEMBL1081094
SMILES: CCN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1ccccc1
InChI Key: InChIKey=JWXKHYYJTARSOV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50313131 (1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs | Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50313131 (1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra... | Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C | |||||||||||
More data for this Ligand-Target Pair |