BDBM50313201 4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid[3-(4-chloro-benzoyl)-phenyl]-amide::CHEMBL1088301

SMILES: OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1cccc(c1)C(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=BALBNZIEZPXHTF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313201   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50313201 (4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...) Show SMILES OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1cccc(c1)C(=O)c1ccc(Cl)cc1 |t:1| Show InChI InChI=1S/C22H15ClN2O5S/c23-15-10-8-13(9-11-15)20(26)14-4-3-5-16(12-14)24-22(28)19-21(27)17-6-1-2-7-18(17)31(29,30)25-19/h1-12,25,27H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISA				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50313201 (4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...) Show SMILES OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1cccc(c1)C(=O)c1ccc(Cl)cc1 |t:1| Show InChI InChI=1S/C22H15ClN2O5S/c23-15-10-8-13(9-11-15)20(26)14-4-3-5-16(12-14)24-22(28)19-21(27)17-6-1-2-7-18(17)31(29,30)25-19/h1-12,25,27H,(H,24,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human COX2 in IL-1beta treated human FF cells assessed as blockade of SnCl2-mediated PGH2 to PGF2alpha conversion after 50 mins by ELIS...				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50313201 (4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...) Show SMILES OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1cccc(c1)C(=O)c1ccc(Cl)cc1 |t:1| Show InChI InChI=1S/C22H15ClN2O5S/c23-15-10-8-13(9-11-15)20(26)14-4-3-5-16(12-14)24-22(28)19-21(27)17-6-1-2-7-18(17)31(29,30)25-19/h1-12,25,27H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISA				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair