BDBM50313214 4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid(3',4'-dichloro-biphenyl-4-yl)-amide::CHEMBL1080852

SMILES: COc1ccc2c(c1)C(O)=C(NS2(=O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=XBXICGFOGCUILQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313214   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50313214 (4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...) Show SMILES COc1ccc2c(c1)C(O)=C(NS2(=O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1 |c:10| Show InChI InChI=1S/C22H16Cl2N2O5S/c1-31-15-7-9-19-16(11-15)21(27)20(26-32(19,29)30)22(28)25-14-5-2-12(3-6-14)13-4-8-17(23)18(24)10-13/h2-11,26-27H,1H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISA				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50313214 (4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...) Show SMILES COc1ccc2c(c1)C(O)=C(NS2(=O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1 |c:10| Show InChI InChI=1S/C22H16Cl2N2O5S/c1-31-15-7-9-19-16(11-15)21(27)20(26-32(19,29)30)22(28)25-14-5-2-12(3-6-14)13-4-8-17(23)18(24)10-13/h2-11,26-27H,1H3,(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human COX2 in IL-1beta treated human FF cells assessed as blockade of SnCl2-mediated PGH2 to PGF2alpha conversion after 50 mins by ELIS...				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50313214 (4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...) Show SMILES COc1ccc2c(c1)C(O)=C(NS2(=O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1 |c:10| Show InChI InChI=1S/C22H16Cl2N2O5S/c1-31-15-7-9-19-16(11-15)21(27)20(26-32(19,29)30)22(28)25-14-5-2-12(3-6-14)13-4-8-17(23)18(24)10-13/h2-11,26-27H,1H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. St. Louis Laboratory Curated by ChEMBL					Assay Description Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISA				Bioorg Med Chem Lett 20: 1604-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.060 BindingDB Entry DOI: 10.7270/Q25X292V
					More data for this Ligand-Target Pair