BDBM50313378 (2R,3S,4S,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3,4-diol::CHEMBL1083834
SMILES: CO[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1ccc(Cl)c(Cc2ccc(OC)cc2)c1
InChI Key: InChIKey=XOOXXVXSVGKKRY-CRSSMBPESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50313378 ((2R,3S,4S,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)ph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs | Bioorg Med Chem Lett 20: 1569-72 (2010) Article DOI: 10.1016/j.bmcl.2010.01.075 BindingDB Entry DOI: 10.7270/Q2DF6RBP | |||||||||||
More data for this Ligand-Target Pair |