BDBM50314612 2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one::CHEMBL1090026

SMILES: CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cnccn1

InChI Key: InChIKey=RXUACQZGEBHKBX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50314612   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50314612 (2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...) Show SMILES CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cnccn1 |c:3| Show InChI InChI=1S/C19H16N6O/c1-25-17(26)19(24-18(25)20,14-5-7-21-8-6-14)15-4-2-3-13(11-15)16-12-22-9-10-23-16/h2-12H,1H3,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of BACE1 by FRET assay				Bioorg Med Chem Lett 20: 2326-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.136 BindingDB Entry DOI: 10.7270/Q28C9WDF
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM50314612 (2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...) Show SMILES CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cnccn1 |c:3| Show InChI InChI=1S/C19H16N6O/c1-25-17(26)19(24-18(25)20,14-5-7-21-8-6-14)15-4-2-3-13(11-15)16-12-22-9-10-23-16/h2-12H,1H3,(H2,20,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of BACE2 by FRET assay				Bioorg Med Chem Lett 20: 2326-9 (2010) Article DOI: 10.1016/j.bmcl.2010.01.136 BindingDB Entry DOI: 10.7270/Q28C9WDF
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50314612 (2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...) Show SMILES CN1C(N)=NC(C1=O)(c1ccncc1)c1cccc(c1)-c1cnccn1 |c:3| Show InChI InChI=1S/C19H16N6O/c1-25-17(26)19(24-18(25)20,14-5-7-21-8-6-14)15-4-2-3-13(11-15)16-12-22-9-10-23-16/h2-12H,1H3,(H2,20,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human BACE1				Eur J Med Chem 46: 58-64 (2010) Article DOI: 10.1016/j.ejmech.2010.10.014 BindingDB Entry DOI: 10.7270/Q2P55PRK
					More data for this Ligand-Target Pair