BDBM50315320 8-chloro-4-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)benzofuro[3,2-d]pyrimidine::CHEMBL1090655

SMILES: Clc1ccc2oc3c(ncnc3c2c1)N1CCN2CCCC2C1

InChI Key: InChIKey=XLTVUPLBQNWVCV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50315320   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50315320 (8-chloro-4-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-y...) Show SMILES Clc1ccc2oc3c(ncnc3c2c1)N1CCN2CCCC2C1 Show InChI InChI=1S/C17H17ClN4O/c18-11-3-4-14-13(8-11)15-16(23-14)17(20-10-19-15)22-7-6-21-5-1-2-12(21)9-22/h3-4,8,10,12H,1-2,5-7,9H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	236	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay				Bioorg Med Chem Lett 20: 2516-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.097 BindingDB Entry DOI: 10.7270/Q2CN74V3
					More data for this Ligand-Target Pair