BDBM50315468 CHEMBL1093792::N-(3,4-difluorophenylsulfonyl)-3-(3-hydroxy-1-(naphthalen-2-ylmethyl)-2-oxoindolin-7-yl)acrylamide

SMILES: OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1

InChI Key: InChIKey=MGAXZCWZAYCFBR-JLHYYAGUSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50315468   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Binding affinity to human EP2 receptor by radioligand displacement assay				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor by radioligand displacement assay				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair
Prostanoid IP receptor (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Binding affinity to human IP receptor by radioligand displacement assay				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair
Prostaglandin F2-alpha receptor (Homo sapiens (Human))	BDBM50315468 (CHEMBL1093792 | N-(3,4-difluorophenylsulfonyl)-3-(...) Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H20F2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15,27,34H,16H2,(H,31,33)/b13-10+	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry Curated by ChEMBL					Assay Description Binding affinity to human FP receptor by radioligand displacement assay				Bioorg Med Chem Lett 20: 2658-64 (2010) Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG
					More data for this Ligand-Target Pair