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SMILES: CS(=O)(=O)c1cccc(c1)-c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1

InChI Key: InChIKey=GBHDCSZQCFDEEU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50315911   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50315911
PNG
(5-(6-(3-(methylsulfonyl)phenyl)-4-morpholinothieno...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H20N6O3S2/c1-32(28,29)15-4-2-3-13(9-15)17-10-16-18(31-17)20(27-5-7-30-8-6-27)26-19(25-16)14-11-23-21(22)24-12-14/h2-4,9-12H,5-8H2,1H3,(H2,22,23,24)
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MMDB

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Article
PubMed
 5n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay

Bioorg Med Chem Lett 20: 2408-11 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.046
BindingDB Entry DOI: 10.7270/Q2GM87FX
More data for this
Ligand-Target Pair