BDBM50316421 (1R,3S)Methyl 1-(2-bromophenyl)-2,3,4,9-tetrahydro-1H-bcarboline-3-carboxylate::CHEMBL1095632

SMILES: COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c1ccccc1Br

InChI Key: InChIKey=QXOOUBWXLCUYFT-DLBZAZTESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50316421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316421 ((1R,3S)Methyl 1-(2-bromophenyl)-2,3,4,9-tetrahydro...) Show SMILES COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c1ccccc1Br |r| Show InChI InChI=1S/C19H17BrN2O2/c1-24-19(23)16-10-13-11-6-3-5-9-15(11)21-18(13)17(22-16)12-7-2-4-8-14(12)20/h2-9,16-17,21-22H,10H2,1H3/t16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assay				Eur J Med Chem 45: 1278-86 (2010) Article DOI: 10.1016/j.ejmech.2009.10.046 BindingDB Entry DOI: 10.7270/Q26W9B6P
					More data for this Ligand-Target Pair