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SMILES: Cc1ccc(cc1)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F

InChI Key: InChIKey=LKQFRCCEWHAKLX-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50316556   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50316556
PNG
(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5...)
Show SMILES Cc1ccc(cc1)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C22H16F4N2O/c1-14-2-4-16(5-3-14)21(29,22(24,25)26)17-6-11-20-15(12-17)13-27-28(20)19-9-7-18(23)8-10-19/h2-13,29H,1H3
PDB

KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 2.09E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay

Bioorg Med Chem Lett 20: 3017-20 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.012
BindingDB Entry DOI: 10.7270/Q23779P9
More data for this
Ligand-Target Pair