null

SMILES: OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F

InChI Key: InChIKey=DXRCWRDHBIVBIS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316562   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50316562 (2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...) Show SMILES OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H12F5N3O/c23-17-3-5-18(6-4-17)30-20-8-2-16(10-14(20)12-29-30)21(31,22(25,26)27)15-1-7-19(24)13(9-15)11-28/h1-10,12,31H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50316562 (2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...) Show SMILES OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H12F5N3O/c23-17-3-5-18(6-4-17)30-20-8-2-16(10-14(20)12-29-30)21(31,22(25,26)27)15-1-7-19(24)13(9-15)11-28/h1-10,12,31H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human ERG by patch clamp method				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50316562 (2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...) Show SMILES OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H12F5N3O/c23-17-3-5-18(6-4-17)30-20-8-2-16(10-14(20)12-29-30)21(31,22(25,26)27)15-1-7-19(24)13(9-15)11-28/h1-10,12,31H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50316562 (2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...) Show SMILES OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H12F5N3O/c23-17-3-5-18(6-4-17)30-20-8-2-16(10-14(20)12-29-30)21(31,22(25,26)27)15-1-7-19(24)13(9-15)11-28/h1-10,12,31H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair