BDBM50316566 (+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol::1-(2,3-DICHLOROPHENYL)-2,2,2-TRIFLUORO-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (ENANTIOMERIC MIX)::1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol::CHEMBL1094208
SMILES: OC(c1ccc2n(ncc2c1)-c1ccc(F)cc1)(c1cccc(Cl)c1Cl)C(F)(F)F
InChI Key: InChIKey=SGKVPHOMCZNDPT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50316566 ((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay | Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50316566 ((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay | Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50316566 ((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Inhibition of human ERG by patch clamp method | Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50316566 ((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 350 | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge... | Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50316566 ((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
AMRI Curated by ChEMBL | Assay Description Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be... | Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9 | |||||||||||
More data for this Ligand-Target Pair |