BDBM50316569 2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)ethanol::CHEMBL1094514

SMILES: Cc1cc(ccc1F)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F

InChI Key: InChIKey=FQPJRGDRIOAJCS-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50316569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50316569 (2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...) Show SMILES Cc1cc(ccc1F)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H15F5N2O/c1-13-10-15(2-8-19(13)24)21(30,22(25,26)27)16-3-9-20-14(11-16)12-28-29(20)18-6-4-17(23)5-7-18/h2-12,30H,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50316569 (2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...) Show SMILES Cc1cc(ccc1F)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H15F5N2O/c1-13-10-15(2-8-19(13)24)21(30,22(25,26)27)16-3-9-20-14(11-16)12-28-29(20)18-6-4-17(23)5-7-18/h2-12,30H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human ERG by patch clamp method				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50316569 (2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...) Show SMILES Cc1cc(ccc1F)C(O)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C22H15F5N2O/c1-13-10-15(2-8-19(13)24)21(30,22(25,26)27)16-3-9-20-14(11-16)12-28-29(20)18-6-4-17(23)5-7-18/h2-12,30H,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...				Bioorg Med Chem Lett 20: 3017-20 (2010) Article DOI: 10.1016/j.bmcl.2010.04.012 BindingDB Entry DOI: 10.7270/Q23779P9
					More data for this Ligand-Target Pair