BDBM50316652 1-(2-ethoxyethyl)-3-methyl-N-(6-methylpyridin-2-yl)-5-(piperazin-1-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1095175

SMILES: CCOCCn1nc(C)c2nc(nc(Nc3cccc(C)n3)c12)N1CCNCC1

InChI Key: InChIKey=XCUNWJSUUNZLPM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50316652   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316652 (1-(2-ethoxyethyl)-3-methyl-N-(6-methylpyridin-2-yl...) Show SMILES CCOCCn1nc(C)c2nc(nc(Nc3cccc(C)n3)c12)N1CCNCC1 Show InChI InChI=1S/C20H28N8O/c1-4-29-13-12-28-18-17(15(3)26-28)24-20(27-10-8-21-9-11-27)25-19(18)23-16-7-5-6-14(2)22-16/h5-7,21H,4,8-13H2,1-3H3,(H,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assay				Bioorg Med Chem Lett 20: 3120-4 (2010) BindingDB Entry DOI: 10.7270/Q2K64K0H
					More data for this Ligand-Target Pair