BDBM50316657 1-(2-ethoxyethyl)-3-ethyl-N-(3-methylpyridin-2-yl)-5-(piperazin-1-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1094517

SMILES: CCOCCn1nc(CC)c2nc(nc(Nc3ncccc3C)c12)N1CCNCC1

InChI Key: InChIKey=FTFLQFFFCFEWQC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50316657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50316657 (1-(2-ethoxyethyl)-3-ethyl-N-(3-methylpyridin-2-yl)...) Show SMILES CCOCCn1nc(CC)c2nc(nc(Nc3ncccc3C)c12)N1CCNCC1 Show InChI InChI=1S/C21H30N8O/c1-4-16-17-18(29(27-16)13-14-30-5-2)20(25-19-15(3)7-6-8-23-19)26-21(24-17)28-11-9-22-10-12-28/h6-8,22H,4-5,9-14H2,1-3H3,(H,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assay				Bioorg Med Chem Lett 20: 3120-4 (2010) BindingDB Entry DOI: 10.7270/Q2K64K0H
					More data for this Ligand-Target Pair