BDBM50317230 (E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(2-(6-((dimethylamino)methyl)pyridin-2-yl)vinyl)-6-methoxyquinoline-3-carbonitrile::CHEMBL1087216

SMILES: COc1cc(Nc2c(cnc3cc(\C=C\c4cccc(CN(C)C)n4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=VWCDZGNJJXNGRD-CMDGGOBGSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50317230   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50317230 ((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(2-(6-...) Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cccc(CN(C)C)n4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H25Cl2N5O2/c1-35(2)16-20-7-5-6-19(33-20)9-8-17-10-24-21(11-26(17)36-3)28(18(14-31)15-32-24)34-25-13-27(37-4)23(30)12-22(25)29/h5-13,15H,16H2,1-4H3,(H,32,34)/b9-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay				Bioorg Med Chem Lett 20: 2924-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.025 BindingDB Entry DOI: 10.7270/Q2J38SR1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50317230 ((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(2-(6-...) Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cccc(CN(C)C)n4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H25Cl2N5O2/c1-35(2)16-20-7-5-6-19(33-20)9-8-17-10-24-21(11-26(17)36-3)28(18(14-31)15-32-24)34-25-13-27(37-4)23(30)12-22(25)29/h5-13,15H,16H2,1-4H3,(H,32,34)/b9-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant Src after 70 mins by FRET assay				Bioorg Med Chem Lett 20: 2924-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.025 BindingDB Entry DOI: 10.7270/Q2J38SR1
					More data for this Ligand-Target Pair