Found 8 hits for monomerid = 50317750 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin receptor
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of InsR |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of PKCalpha |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
High affinity immunoglobulin gamma Fc receptor I
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of IGFR1 |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of TrkA |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of LcK |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MK2 |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50317750
(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)Show SMILES Fc1ccc(NC(=O)c2cccnc2Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)c(F)c1 Show InChI InChI=1S/C25H16F3N5O2/c26-14-3-5-20(18(27)12-14)33-25(34)17-2-1-9-29-24(17)32-15-4-6-22(19(28)13-15)35-21-8-11-31-23-16(21)7-10-30-23/h1-13H,(H,29,32)(H,30,31)(H,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
Bioorg Med Chem Lett 20: 2998-3002 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM |
More data for this Ligand-Target Pair | |