BDBM50317756 2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2-(2-hydroxyethyl)phenyl)nicotinamide::CHEMBL1097543

SMILES: OCCc1ccccc1NC(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1

InChI Key: InChIKey=TZKKFIHYCVSIQC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50317756   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50317756 (2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...) Show SMILES OCCc1ccccc1NC(=O)c1cccnc1Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 Show InChI InChI=1S/C27H22FN5O3/c28-21-16-18(7-8-24(21)36-23-10-14-31-25-19(23)9-13-30-25)32-26-20(5-3-12-29-26)27(35)33-22-6-2-1-4-17(22)11-15-34/h1-10,12-14,16,34H,11,15H2,(H,29,32)(H,30,31)(H,33,35)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation counting				Bioorg Med Chem Lett 20: 2998-3002 (2010) Article DOI: 10.1016/j.bmcl.2010.01.042 BindingDB Entry DOI: 10.7270/Q2PN95TM
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