BDBM50318012 2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(6-methylpyridazin-3-yl)benzamide::CHEMBL1094736

SMILES: Cc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1

InChI Key: InChIKey=RVHUTADMAUFBCK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50318012 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(6-met...) Show SMILES Cc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C20H24ClN3O2/c1-14-6-9-18(24-23-14)15-7-8-17(21)16(12-15)19(25)22-13-20(26)10-4-2-3-5-11-20/h6-9,12,26H,2-5,10-11,13H2,1H3,(H,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer St. Louis Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 20: 3107-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.094 BindingDB Entry DOI: 10.7270/Q2D50N4Q
					More data for this Ligand-Target Pair