BDBM50318142 3-methyl-N-(4-methylpyridin-2-yl)-5-(piperazin-1-yl)-1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1098654

SMILES: Cc1nn(CCOCC(F)(F)F)c2c(Nc3cc(C)ccn3)nc(nc12)N1CCNCC1

InChI Key: InChIKey=JPPXWCPFACXJOK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318142 (3-methyl-N-(4-methylpyridin-2-yl)-5-(piperazin-1-y...) Show SMILES Cc1nn(CCOCC(F)(F)F)c2c(Nc3cc(C)ccn3)nc(nc12)N1CCNCC1 Show InChI InChI=1S/C20H25F3N8O/c1-13-3-4-25-15(11-13)26-18-17-16(27-19(28-18)30-7-5-24-6-8-30)14(2)29-31(17)9-10-32-12-20(21,22)23/h3-4,11,24H,5-10,12H2,1-2H3,(H,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
					More data for this Ligand-Target Pair