BDBM50318147 3-ethyl-5-(4-methyl-1,4-diazepan-1-yl)-N-(pyrimidin-4-yl)-1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1095760

SMILES: CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N1CCCN(C)CC1

InChI Key: InChIKey=HMXWWEZJHIDDEP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318147 (3-ethyl-5-(4-methyl-1,4-diazepan-1-yl)-N-(pyrimidi...) Show SMILES CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N1CCCN(C)CC1 Show InChI InChI=1S/C21H28F3N9O/c1-3-15-17-18(33(30-15)11-12-34-13-21(22,23)24)19(27-16-5-6-25-14-26-16)29-20(28-17)32-8-4-7-31(2)9-10-32/h5-6,14H,3-4,7-13H2,1-2H3,(H,25,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
					More data for this Ligand-Target Pair