BDBM50318152 4-(3-ethyl-7-(pyrimidin-4-ylamino)-1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperazin-2-one::CHEMBL1095455

SMILES: CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N1CCNC(=O)C1

InChI Key: InChIKey=KGOFUSVXUVEEPT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318152 (4-(3-ethyl-7-(pyrimidin-4-ylamino)-1-(2-(2,2,2-tri...) Show SMILES CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N1CCNC(=O)C1 Show InChI InChI=1S/C19H22F3N9O2/c1-2-12-15-16(31(29-12)7-8-33-10-19(20,21)22)17(26-13-3-4-23-11-25-13)28-18(27-15)30-6-5-24-14(32)9-30/h3-4,11H,2,5-10H2,1H3,(H,24,32)(H,23,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
					More data for this Ligand-Target Pair